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Intracytoplasmic phosphorylation sites of Tac antigen p55 are not essential for the conformation, 44610, and regulation of the human interleukin 2 receptor. BK viral enhancer element and a human cellular homolog. The human beta-interferon gene enhancer is under negative control.

Accurate transcription initiation by RNA polymerase II in a irrf extract from isolated mammalian nuclei. A rapid and sensitive assay system for bacterial gpt activity in transfected mammalian cells.

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IRF-1 may also be involved in silencing the idf of the SV40 enhancer juxtaposed to the regulatory elements in uninduced cells. Reversible silencing of enhancers by sequences derived from the human IFN-alpha promoter.

This article has been cited by other articles in PMC. Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase. Affinity purification of sequence-specific DNA binding proteins.

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Controlled transcription of a human alpha-interferon gene introduced into mouse L cells. Please review our privacy policy. Regulation of gene expression by interferons: Identification of two distinct regulatory regions adjacent to the human beta-interferon gene. Heat shock factor is regulated differently in yeast and HeLa cells.

Transcription of the human interferon-beta IFN-beta gene is induced by a variety of agents such as viruses, dsRNA and some cytokines.

Abstract Transcription of the human interferon-beta IFN-beta gene is induced by a variety of agents such as viruses, dsRNA and some cytokines. Establishment of a permanent cell line HEL-R66 from human embryonic lung cells with high iff to viruses. Human beta-interferon gene expression is regulated by an inducible enhancer element.

Associated Data Idf Materials. National Center for Biotechnology InformationU. Interaction of positive and negative regulatory proteins in the galactose regulon of yeast. A nucleotide promoter segment from an IFN-alpha gene renders an unrelated promoter inducible by virus.

Regulation of cytokine gene expression. Support Center Support Center. High jrf DNA-mediated transformation of primate cells. Human embryonic lung cells HEL-R66 are of monkey origin. In this study, we describe a nuclear factor, termed interferon regulatory factor-1 IRF-1that is involved in the transcription of IFN-beta and possibly other ief. Our data suggest that IRF-1 participates in the transient formation of an induction-specific complex es with the regulatory elements. Images in this article Image on p.

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Open in a separate window. Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.

A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Structure of a chromosomal gene for human interferon beta.

Delimitation and properties of DNA sequences required for the regulated expression of human interferon-beta gene. The 5′-flanking sequence of human interferon-beta 1 gene is responsible for viral induction of transcription. Biochemistry of interferons and their actions.

Short and long irv activation by the SV40 enhancer. Author information Copyright and License information Disclaimer. krf

Changes of chromatin conformation around mouse interferon-beta gene associated with induction of interferon synthesis. Sequencing end-labeled DNA with base-specific chemical cleavages.

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